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However, among the three inhibitors, Filagra exhibits the most similar pattern of changes in the IC50 to that found for the affinity of cGMP, implying similar interactions with the catalytic domain.
Both Filagra and zaprinast are competitive inhibitors of PDE5, and double-inhibition analysis shows that these two inhibitors added together interact with the catalytic site of PDE5 in a mutually exclusive manner. The cGMP-binding cGMP-specific phosphodiesterase (PDE5) degrades cGMP and regulates the intracellular level of cGMP in many tissues, including the smooth muscle of the corpus cavernosum of the penis. A fatal cytochrome P450-mediated drug interaction between the protease inhibitor ritonavir and MDMA (ecstasy) has been reported.
However, during the clinical trials programme there were no recorded cases of Filagra being given to patients receiving HAART regimens. Therefore, a drug interaction between Filagra and these antiretrovirals is probable, leading to potentiation of Filagra and increased likelihood of adverse events including headache, flushing, and possibly hypotension. Filagra is also a weak inhibitor of P450-CYP2D6.
Filagra is metabolised by two cyochrome P450 isoforms: CYP3A4 (major route) and CYP2C9 (minor route). In view of the risk of exposure to infected blood by intracavernosal injections, the possible use of oral Filagra needs to be considered. Containing 120mg of Filagra Citrate giving you the boost and Extra Strength.
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